![]() ![]() And/or prothrombin complex concentrate (immediate antidote).Vitamin K antagonism ( γ- carboxylation of clotting factors) → excessive bleeding.Benzodiazepines for control of seizures.Sodium bicarbonat e (to stabilize cardiac cell membrane).Muscarinic ACh receptor inhibition → anticholinergic syndrome (see tricyclic antidepressant toxicity).Catalyze conversion of plasminogen to plasmin → excessive bleeding.Thrombolytic agents (e.g., recombinant tPA) Salicylate metabolites accumulate in liver → hepatic failure and metabolic acidosis (see salicylate toxicity).μ-, κ-, and δ- receptor agonism (see opioid intoxication) → miosis, altered mental status, respiratory depression. ![]() Increases activity of antithrombin → excessive bleeding.Renal elimination → supratherapeutic levels → excessive bleeding, acute renal failure.Inhibits Na+/K+-ATPase → cardiac arrhythmias, xanthopsia (see cardiac glycoside poisoning).Insulin and glucose to correct hypoglycemia.Glucagon: increases cardiac contractility.Inhibit sympathetic effect → bradycardia, hypotension, hypoglycemia (see beta blocker overdose).Enhance action of GABA → CNS depression (see benzodiazepine overdose). ![]()
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